Choose the kind of molecular subtype predictor you want to use to define patients' molecular subtypes:
single sample predictors (SSPs), subtype clustering models (SCMs), or all.
Once the criteria have been chosen, click on "Submit".
After submission, a validation page shows information about the gene tested
and indicates number of patients and number of events in each subtype, before and after filtering, for the molecular subtyping method(s) chosen.
After visualising the validation screen, you can decide to validate or cancel your submission.
"Start analysis" will launch
with the chosen gene and direct you to molecular subtype prognostic analysis result page.
"Cancel" will redirect you back to previous screen, and offer you to choose a new gene.
Results are presented in one or 2 tables, depending on the number of subtyping methods chosen, summarizing analysis results
(Cox p-values and hazard ratios with 95% confidence interval, expression level for patients with good prognosis,
number of patients and events) for each molecular subtype.
Links to Kaplan-Meier curves are embedded in the table.
Gene results are displayed for each subtype defined by each predictor of the molecular subtyping method(s) chosen.
This analysis permits to evaluate the prognostic informativity of the gene per molecular subtype.
curve associated with the molecular subtype predictor can be visualise by clicking on the link embedded in the table.