After submission, a validation page shows detailed information about tested gene or probe and:
- number of patients from original studies tested,
- 1 complete data before filtering;
2 results of filtering process,
- 3 if the gene is found or not; and
4 patients finally analysed (if no missing genomic data).
At this step, you can validate or cancel your submission according
to these intermediate descriptive data summarized at the bottom of this page.
"Start analysis" will launch
with the chosen gene and direct you to exhaustive analysis results page.
"Cancel" will redirect you back to previous screen, and offer you to choose a new gene.
Results are displayed in a table for all subgroups defined by different nodal, oestrogen receptor and event status
ordered by p-value (smallest to largest).
Significant results may be considered robust if more than 5 combinations
among the 18 give a significant result.
If there are only 5 combinations or less with a p-value<0.05,
one cannot exclude a false discovery problem. However, if more
than 5 combinations give a significant result, the risk of false positive
rapidly decreases (6 or more, p<0.03; 7 or more, p<0.007;
8 or more, p<0.002; 9 or more, p<0.001).
In result table of exhaustive prognostic analysis, you can run a "targeted prognostic analysis" by clicking on population
(Node or ER status) or event (MR or AE) criteria on corresponding line. In this case, validation step is bypassed.