Integrated Center for Oncology

Breast Cancer Gene-Expression Miner v4.2
(bc-GenExMiner v4.2)

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Targeted prognostic analysis Tutorial

Enter input gene(s) and choose the following options:

  • GENE Open
  • Fill the textbox with actualised* gene symbol or Affymetrix probeset ID.

    *: see actualised web databases (e.g.: GeneCards, Source, Unigene...)

    @: the probesets followed by "@" are described as references for subtyping ER, PR and HER2 status by means of genomics data. See Kenn et al..


  • POPULATION Open
  • Choose the characteristics (nodal and oestrogen receptor status) of the cohorts to be explored.  Mixed status includes patients with any status.

    Choose the kind of event used for survival analyses:
    • "metastatic relapse": first pejorative event represented by distant relapse.
    • "any event": first pejorative event represented by any relapse or death
    These datasets are retrieved from published annotated genomic data.

  • Nodal status:
  • Oestrogen receptor status:
  • Event status:
  • DISCRETISATION Open
  • Choose one of the radio button to select which splitting method you want to explore for prognostic study:
    • "mediane": 2 groups split at 50%,
    • "tertile": 3 groups split at 33%,
    • "quartile": 4 groups split at 25%,
    • "optimal": 2 groups split at the best cut-off (more info)
    • "custom percentile": 2 groups split at the user cut-off.

  • Splitting criterion:


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    2019